Alteration of Experimental Poliomyelitis Infection in the Syrian Hamster with the Aid of Cortisone
نویسندگان
چکیده
Cortisone produces a significant enhancement of infection with MEF1 and Lansing strains of poliomyelitis virus in the Syrian hamster. The enhancement manifests itself in increased severity of symptoms, shortening of the incubation period, marked reduction in survival time and a high mortality rate. The effect of cortisone is protracted, the duration depending on the dose used. There is a reciprocal relationship between the dose of cortisone and the amount of virus, the larger the dose of the hormone, the smaller the amount of virus being necessary to produce the infection. An amount of virus of low infectivity causes amarked disease with a high mortality rate in hamsters receiving a single injection of 3 mg. of cortisone, while a dose as small as 2 mg. gives a highly fatal disease with a stronger concentration of the virus. There is a 2 log increase in the concentration of the virus in cortisone-treated hamsters. Hamsters from various sources seem to respond differently to the enhancing effect of cortisone, one breed showing no enhancement of the infection with the Lansing strain. Hormones other than cortisone, i.e., DCA, progesterone, diethylstilbestrol, and fast and slow acting ACTH injected repeatedly fail to modify the poliomyelitis infection in the hamster.
منابع مشابه
Relation of Certain Endocrine Disturbances to Susceptibility of Golden Syrian Hamster to Experimental Poliomyelitis
Alterations in susceptibility of the Syrian hamster to poliomyelitis virus (MEF1) inoculated intracerebrally appeared closely related to seasonal changes and experimental disturbances in the adreno-testes equilibrium. Enhanced susceptibility coincided with seasonal enlargement of adrenals, followed cortisone and DOCA treatment and appeared during the initial postorchiectomy period. Increased re...
متن کاملEffects of cortisone on experimental murine typhus. I. Susceptibility of the Syrian hamster to murine typhus and the effect of cortisone.
Investigators who study rickettsial diseases are interested in finding an animal highly susceptible to these diseases. The lack of such an animal has prompted the investigation of numerous animals and the use of various techniques to increase their susceptibility. This is well demonstrated in the literature concerning murine and epidemic typhus. Although the guinea pig, cotton rat, and mouse ar...
متن کاملSpontaneous differentiated squamous cell carcinoma of cheek pouch in a Syrian hamster
A 2-year-old male hamster was presented because of left facial swelling and salivation. Necropsy wasperformed and affected cheek pouch with tissue samples of regional and internal organs were submitted forhistopathological study. In histopathological examination it was found that the tumor consisted of cords andislands of tumoric epithelial cells which were diffused in the dermis. Vacoulation o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 95 شماره
صفحات -
تاریخ انتشار 1952